Endocrine Abstracts

All domains of life feature diverse molecular clock machineries that synchronize physiological processes to diurnal environmental fluctuations. However, no mechanisms are known to cross-regulate prokaryotic and eukaryotic circadian rhythms in multi-kingdom ecosystems. We discovered that the intestinal microbiota, in both mice and humans, exhibits diurnal oscillations, leading to time-specific compositional and functional profiles over the course of a day. The active phase of t...